1/17/2024 0 Comments Eddie izzard dress to killThe following year, Izzard released her second stand-up special, "Eddie Izzard: Unrepeatable" (1994) and made her West End dramatic debut as the lead in the premiere of David Mamet's play, "The Cryptogram." Well received on stage, Izzard went on to land starring roles in David Beaird's black comedy, "900 Oneonta" and a 1995 production of Christopher Marlowe's "Edward II." Making her feature film debut in 1996, Izzard appeared as the devious anarchist-ambassador Vladimir in "The Secret Agent" (1996), Christopher Hampton's take on the Joseph Conrad novel. Finally hitting her mark, the show was extended past its original four-week run and was later taped and released on video as "Eddie Izzard: Live at the Ambassadors" (1993), winning Izzard the British Comedy Award for Top Stand-Up Comedian. By the early 90's, Izzard's growing popularity allowed her to take on larger venues around London in February of 1993, she landed her first stand-up gig at The Ambassador's Theatre in London's West End. Taking to the improvisational stage in 1987, Izzard made her first appearance at The Comedy Store in London, where she began to hone her stand-up routine. Though these stunts, which involved swordplay and unicycle tricks, were not particularly well-received, Izzard began to build strong improvisational skills that would later serve her well in stand-up. After "coming out" as a straight transvestite in 1985 (she had a penchant for dresses since the age of four and was caught stealing makeup as a teenager), Izzard and a friend began performing comedy stunts in London's Covent Garden. Focusing on her acting, Izzard staged shows at the university and at the Edinburgh Fringe Festival, looking for a way to take her performance to a professional level. Spending most of her time writing and performing comedy shows instead, Izzard's attention to her degree only lasted a year. She went on to attend Sheffield University as an accounting and financial management major. Finally cast in a small role at the age of 15, Izzard appeared as the jailer in a production of Shakespeare's "Comedy of Errors." Handcuffed to the lead during part of the play, Izzard managed to upstage her fellow performer, and was later cast in a number of other plays. As a child at Eastbourne College, Izzard developed an interest in acting and began auditioning for a number of school plays, but found little success. After her mother died of cancer when she was only six-years old, Izzard and her older brother were sent to Eastbourne, England to attend boarding school. 7, 1962 in Aden, Yemen to English parents Harold Izzard, an accountant for British Petroleum, and Dorothy Izzard, a nurse, Izzard grew up in Bangor, Northern Ireland before relocating to Skewen, Wales in 1967. With a wit and style all her own, Izzard proved to be one of the world's most interesting and versatile performers. On the stage, Izzard has starred in performances of "A Day in the Death of Joe Egg" in both London and New York, and on screen, appeared in numerous films, including "Shadow of the Vampire" (2000), "Ocean's Twelve" (2004) and "Valkyrie" (2008). A world performer, Izzard often performed her stand-up in different languages, ably speaking fluent French which impressed that country and its denizens. One of her most popular stand-up routines, "Kill" later won Izzard two Emmy Awards. Making a lasting impression on American audiences in her fifth major stand-up tour, "Eddie Izzard: Dress to Kill," (1999), Izzard combined such unrelated topics as the army, makeup, and the Church of England. A self-professed "executive transvestite," Izzard's eclectic style and gender-bending wardrobe was often a trait that set her apart from the pack. A witty, intelligent and unique performer, Izzard's stream-of-consciousness, non-sequitur style of comedy made her one of the top comedians in the business, as well as a successful film and stage actor. The Kids in the Hall: Comedy Punks (2022)Ī self-deprecating yet cheeky British comedian with a penchant for eyeliner, Suzy Eddie Izzard was hailed as the "greatest British stand-up comedian of her generation" by The London Sunday Times.
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1/17/2024 0 Comments Toyo baby and timi adigunShe had in an earlier post called out the pastor who was her ‘Spiritual father’ for taking control of her Facebook and other social media accounts.īut in reaction, Adigun, who is the lead pastor of Mine Teens ministry, denied that he had the passwords to the social media accounts of the actress. Juliana claimed that her former manager Pastor Timi Adigun was responsible for her exit from the hit series. Juliana, who is also an author, is famed for her role in ‘Jenifa’s Diary’, a comedy series by Funke Akindele-Bello.īut she stopped featuring in the show from May 2016. The next I want to see is a subpoena.Actress Juliana Olayode aka Toyo Baby has opened on how she was dropped from hit series Jenifa’s Diary. What I was guilty of, I owned up to and apologised for. I NEVER sexually abused anyone! I have facts, figures and dates. “When you know you have told the truth, there is no more fear. “That said, I want to make it public here that I am ready to stand before any court or panel and I am ready to be investigated. I have to speak the truth but it is still up to individuals to choose what to believe. “I have been brought before a social media jury. “For those concerned for me and asking me to stop responding, if I was brought before a court, I would have to talk or my lawyer would talk. READ ALSO: ‘I Just Hope That The Girls At Yeshua High School Are Safe’ -Juliana ‘Toyo Baby’ Oloyede Opens A Can Of Worms As She Accuses Popular Pastor, Timilehin Adigun Of Sexually Abusing Her Sister, Others He added that he hopes Juliana will find peace. The married pastor denied the sexual assault allegation and said he’s ready to go to court to defend himself. Timi who pastors the Haven of Love Church, has now reacted. She said he apologized to her family but the apology just wouldn’t do. Responding, Juliana alleged that Timi Adigun sexually molested her younger sister which is why she couldn’t forgive him. He told her that he raised her and she has no reason to call him by his name. The pastor also lashed Juliana for calling him by name when she came to his church to confront him about her password. He further told her that he knows many of her secrets but won’t reveal it to the world because he is her “father”. He went on to explain why he unpublished her Facebook account. He admitted that he used her Facebook account to make a post but when she called him out on Instagram about it, he deleted it. He went on to tell her that he initially held on to her Facebook account, hoping she will one day come back to him. He further stated that she left his church in 2020 after saying that she could not forgive him for something he did, which he already apologized for. He added that he gave her all her passwords when he created the accounts. The pastor responded, stating that he created all her social media accounts, including YouTube, Instagram, and Facebook for free as a father would. Juliana popularly known as Toyo Baby had on Tuesday called out Adigun, who was her ‘spiritual’ father and manager, for taking control of her Facebook and other social media accounts. Pastor Timilehin Adigun has reacted to actress, Juliana Oloyede‘s latest claim that he sexually abused her sister, which is why she couldn’t forgive him and had to leave his church. 1/17/2024 0 Comments Baby diet coke caffeineFish high in mercury, such as king mackerel, marlin, orange roughy, shark, swordfish, tilefish (from the Gulf of Mexico), and bigeye tuna should be avoided.Check the Nutrition Facts Label to find foods with less salt. Some snack foods and store-bought packaged toddler foods are high in salt. Foods high in salt (sodium), such as some canned foods, processed meats (e.g., lunch meats, sausages, hot dogs, ham), and frozen dinners should be avoided.Children younger than 24 months old should avoid added sugars. These drinks are different than 100% juice. Sugar-sweetened drinks (such as soda, pop, soft drinks, flavored milks, sports drinks, flavored water with sugar, and juice drinks) contain added sugars.Check the Nutrition Facts Label to find foods with no added sugars. Foods with added sugars can include muffins, flavored yogurts, or cookies. Foods with added sugars, low-calorie sweeteners, or no-calorie sweeteners are not recommended.Unpasteurized milk can also be called raw milk. Do not give your child unpasteurized drinks or foods such as juice, milk, yogurt, or cheeses. Unpasteurized drinks or foods (such as juices, milks, yogurt, or cheeses) may put your child at risk for a harmful bacteria that can cause severe diarrhea.Do not add honey to your baby’s food, water, infant formula, or on their pacifier. Before your child is 12 months old, do not give him or her any honey. Honey before 12 months may cause a serious type of food poisoning called botulism. 1/17/2024 0 Comments Dropzone 4 for ios instal freeThen they changed the policy to making people wait 60 days for a gift card. They used to have instant gift cards available 24/7. Now it’s an absolute scam and customer service knows it and doesn’t care. Scam app! Please don’t let them profit off your data.ĭrop used to be the best for earning cash back by shopping online and playing games. Love that you can connect credit cards & it doesn’t have to be your bank if you don’t want to. The poor people whose phones can’t upgrade are locked out completely until it’s fixed. But the fact you can’t access the deals or cash out on the website & only the app (some offers can be activated on a chrome extension) makes me worried for the future of this app. If I can’t cash out it doesn’t matter how many points I can or can’t earn.ġ) cash outs have become much harder you have to race all the other users on a Thursday now 2) listing here says it works on iOS 13 & up but as of the last two updates it actually only works on the latest iOS 17. However the basketball & snake games appear to be missing (but I still have a notification saying I have games available to play?) If they are truly gone it’s sad since that cuts some of the points I can earn. *Limited quantities of gift cards are available at a specific weekly time windowĮDIT: as of yet another update the app is once again working on iOS 16! My “Pet” was crying from not having seen me but survived. No more coupon clipping or receipt scanning.ĭownload the free Drop app to uncover next-level deals and start earning cash rewards today.įollow us to stay up-to-date on our latest deals, contests, and giveaways:įacebook: Instagram: Twitter: Need help? Reach out to our Twitter Support channel: () Now that’s a win, win! Use Stacked Deals to find sales and special limited-time offers at your favorite brands AND earn rewards points back on those purchases when you shop with Drop.ģ. Stack your savings: Earn points with Drop, and with your credit card. Get a little something back every time you shop.Ģ. Guilt-free shopping: Splurge without that sinking feeling. Earn points when you complete quick, simple surveys through the appġ. Earn points by shopping, receive cash back for every purchase & use points for gift cards, win-win-win!.Link your card to receive points, then shop to receive even more points!.Your credit card becomes a Drop rewards card when you shop through the app.Shop and save points to redeem for gift card rewards at your favorite stores!.
1/17/2024 0 Comments Paperwhite kindle readerPaul Hollywood and Prue Leith Savaged Josh in 'The Great British Baking Show' Finale Why Is Matt Lucas Back Co-Hosting 'The Great British Baking Show: Holidays'? ‘The Great British Baking Show: Holidays’ Highlights Where the Main Series Might Be Going Wrong Stream It Or Skip It: 'The Great British Baking Show: Holidays' 2023 on Netflix, A Festive and Funny Pair of Holiday Episodes 'The Gilded Age' EP Teases How the Season 2 Finale Sets Up "Fireworks" Between Agnes and Ada in Season 3 How 'The Gilded Age' Season 2 Finale Pulled Off Its Massive Metropolitan Opera House Reveal What We Know So Far About 'The Gilded Age' Season 3 Stream It Or Skip It: ‘American Symphony’ on Netflix, Where Musician Jon Batiste Works to Reinvigorate The Classical Form While Confronting Personal Life Peril 'Crock Of Gold: A Few Rounds With Shane MacGowan' Is Epic Tale Of Blarney And Braggadocio Shane MacGowan: Pogues Frontman And "Fairytale of New York" Singer Dead At 65 Stream It Or Skip It: ‘Taylor Swift: The Eras Tour,’ A VOD Version Of The Superstar’s Hit Concert Film With Three Bonus Performances Jason Momoa's Gyrating Pelvis Forced An Flustered Kelly Clarkson To Change The Subject In Wild Daytime TV Momentĭick Van Dyke Believes He's "A Lazy Person" And Credits Luck For His Decades-Long Career In The Entertainment Industry: "There Was Always Somebody Who Picked Me Up And Put Me Over There" Hannah Waddingham Calls Out Jason Sudeikis For Ending 'Ted Lasso': "We Miss It, Jason!" Kelly Ripa Jokes About The 'Live' Holiday Party Where Producers "Compete For Their Holiday Bonuses": "I Have Never Seen Such Vicious Bloodsport Over A $10 Gift Card" Is 'The Zone Of Interest' Streaming on Netflix or HBO Max? Stream It Or Skip It: 'Finestkind' On Paramount+, A Languidly-Paced Film About Fishing, Brothers, Fathers And Sonsīradley Cooper Makes The Case For Not Having Chairs On Set: “Your Energy Dips The Minute You Sit Down In A Chair” Stream It Or Skip It: ‘Barbie’ on HBO Max, Where Greta Gerwig Makes Clever, Intelligent, Unfailingly Funny Art Out of Corporate IP 'Barbie' Director Greta Gerwig Shares That Ken's Faux Mink Coat Was Inspired By Her And Ryan Gosling’s Mutual And "Very Deep Love Of Sly Stallone": "He Wore Wonderful Coats" James Cameron Praises 'Barbie' Monologue To Greta Gerwig: "You Basically Sum Up Thousands Of Years Of The Female Dilemma In One Minute" Stream It Or Skip It: 'Trevor Noah: Where Was I' On Netflix, The Comedian Gets A Lot Of Applause For Addressing America's Place In The World Movie’ on Netflix, a Perfectly Fine Family Movie Further Proving That IP is King Stream It Or Skip It: ‘The Super Mario Bros. Stream It Or Skip It: ‘Baby Shark’s Big Movie!’ on Paramount+, a Feature-Length Animated Earworm (That Might Secretly Be A Commentary On Taylor Swift?!?) Where to Watch the 'Willy Wonka' Movies Before 'Wonka' Here’s Why Mel Gibson Is Not in ‘Chicken Run: Dawn of the Nugget’ Stream It Or Skip It: ‘Designing Christmas With You’ on GAF, in Which Two Stubborn People Decorate A House For Work Before The Holidays Stream It Or Skip It: 'The Secret Gift of Christmas' on Hallmark Channel, About A Personal Shopper Who Falls For Her Client While Doing His Holiday Shopping Stream It or Skip It: 'Friends & Family Christmas' on Hallmark, Where Fake Dating Leads to Something Special for Two Women During the Holidays Stream It or Skip It: 'Merry Magic Christmas' on Lifetime, Where a Math Lady and Theater Guy Come Together to Save a Business and Find Love For the negative: our trip started off very poorly, we had called in advanced and were promised a quiet room in a quiet part of the hotel. We thought the food options to be good and well-priced. For the most part, we found the staff in the rest of the resort to be very attentive and friendly. The lifeguards were always on the move looking in the pools to make sure they had it totally covered. I will start with the most positive: it is clear the resort takes safety very seriously. We had a very mixed experience at Great Wolf Lodge. If our 7yo and 9yo would have been with us, they would have loved the water park but my encompassing opinion wouldn’t have changed. Over all it was enjoyable but I would hesitate to recommend it to a friend. I would have rather stayed at a different chain hotel or air b&b for 1/3 of the price and spent the rest of our money on local excursions and local businesses instead of here. When you are spending that kind of money on a hotel/amenities, you expect the form fit and function to meet or exceed your expectations. Overview: I wouldn’t pay the price tag again unless there were some small renovations completed. The waterpark staff were constantly sanitizing multi touch surfaces regularly which was good to see. Lines were short and there were plenty of rafts for those needing them. It seemed like the right amount of people for the amount of space available with social distancing. If they are operating on limited guest capacity I wouldn’t want to see what full capacity was. Waterpark: our son is only 14m so we were in small child areas and the lazy river. Since checkout I emailed customer support and received a small room credit back to us and was advised they are not cleaning rooms unless requested due to covid (which I had directly asked the front desk staff and was told that was not why our room wasn’t cleaned, and we were not told at check in, so there is a miscommunication here somewhere). We returned at 9 and our room still had not been cleaned so I requested extra towels and informed the front desk again our room hadn’t been cleaned. Sunday our room was not cleaned all day I called the front desk and asked if this was due to covid and they said no, so I requested for our room to be cleaned as we were leaving again at 4pm and would not be returning until around 9pm. We arrived on a Saturday and left Monday morning. Carpet around the tile had come up and was damaged with exposed tack strip, which wasn’t ideal for a curious 1 year old. The tub was clean with extra towels but the mirror was a bit damaged and delaminated. Room: we splurged on a jacuzzi room for our 2 night stay. The staff at Great Wolf Lodge looks forward to serving you during your upcoming visit. Looking to explore? Then look no further than The Village at Grand Traverse Commons (1.2 mi), The Botanic Garden (0.6 mi), and World's Largest Cherry Pie Pan (1.1 mi), which are some popular Traverse City attractions – all conveniently located within walking distance of the resort. While in Traverse City, you may want to check out some of the restaurants that are a short walk away from Great Wolf Lodge Traverse City, including Trattoria Stella (1.1 mi), PepeNero (1.2 mi), and Spanglish (1.2 mi). As an added convenience, there is free parking available to guests. In addition, guests can enjoy a pool and a lounge during their visit. You can also take advantage of some of the amenities offered by the resort, including room service. Guest rooms offer a flat screen TV, air conditioning, and a kitchenette, and Great Wolf makes getting online easy as free wifi is available. Given the close proximity of popular landmarks, such as Front Street (2.2 mi) and Boardman River Boardwalk (2.3 mi), guests of Great Wolf Lodge Traverse City Mi can easily experience some of Traverse City's most well known attractions. If you’re looking for a family-friendly resort in Traverse City, look no further than Great Wolf Lodge.
1/16/2024 0 Comments Angela anaconda voice actorHe has two brothers, Barry Voight, a former volcanologist at Pennsylvania State University, and James Wesley Voight, known as Chip Taylor, a singer-songwriter who wrote " Wild Thing" and " Angel of the Morning". Jonathan Vincent Voight was born on December 29, 1938, in Yonkers, New York, to Barbara ( née Kamp) and Elmer Voight ( né Voytka), a professional golfer. He is the father of actress Angelina Jolie and actor James Haven. He also appeared on the thriller series 24 in its seventh season.ĭespite originally adopting liberal views, Voight has gained attention in his later years for his outspoken conservative and religious beliefs. His role as Mickey Donovan on the Showtime drama series Ray Donovan brought him newfound acclaim and attention among critics and audiences, as well as his fourth Golden Globe win in 2014. Voight is also known for his television roles, including as Nazi officer Jürgen Stroop in Uprising (2001) and Pope John Paul II on the eponymous miniseries (2005). He is also known for his role in the National Treasure film series. Other notable credits include roles in Heat (1995), Mission: Impossible (1996), The Rainmaker (1997), Enemy of the State (1998), Pearl Harbor (2001), Holes (2003), Glory Road (2006), and Transformers (2007). He received a Golden Globe Award and was nominated for an Academy Award for his role in Runaway Train (1985).įor his portrayal as sportscaster Howard Cosell in Ali (2001), he earned nominations for the Academy Award and a Golden Globe Award. During the 1970s, he played a businessman mixed up with murder in Deliverance (1972) a paraplegic Vietnam veteran in Coming Home (1978), for which he won an Academy Award for Best Actor and a penniless ex-boxing champion in the remake of The Champ (1979). The role earned him a BAFTA Award and Golden Globe Award. Voight first came to prominence for his performance as Joe Buck, a would-be gigolo, in Midnight Cowboy (1969). In 2019, he was awarded the National Medal of Arts. He has received numerous accolades, including an Academy Award, a BAFTA Award, and four Golden Globe Awards as well as nominations for four Primetime Emmy Awards. Voight is associated with the angst and unruliness that typified the late-1960s counterculture. By the end of the episode, they finally reunited when February fell onto September's turntable during a dance, making him happy again.Jonathan Vincent Voight ( / ˈ v ɔɪ t/ born December 29, 1938) is an American actor. Although February said she would be at the train station, she never showed. Eventually, a dog war broke out and they had to flee Paris before the invasion. Only after bidding (thus showing forgiveness) to Repunzil after he had shooed her away earlier, she did open the can so he could eat his food.Īs revealed in the Valentine's Day special, September once had a girlfriend called February, who was a cat. Despite his natural intelligence, he can't seem to open a simple can of dog food due to not having any thumbs. September also has a contract that permits him to have at least one day off. Despite that, he does enjoy the company of the Off-Beats. He is a sarcastic, blond-furred talking dog who is paid by Betty Anne Bongo to like August (even though he was paid, he once proclaimed, that he has a slight 1% liking for August, while 99% of it is hatred). September is a character on The Off-Beats, seen on the Nickelodeon animated sketch comedy series KaBlam!. KaBlam! James KaBlam! (KaBlam!), An Off-Beats Valentine's ( Nickelodeon) You've Tried The Rest! Now Try The Best! (KaBlam!) KaBlam! (Better Than A Poke In The Eye), The Off-Beats Unknown, though he appears to be of adult age 1/16/2024 0 Comments Best margarita recipe agaveStir to combine, then top it with ice, stirring again for another 30 seconds, or until the pitcher is frosty on the outside. Muddle with the back of a wooden spoon, then add 16 oz tequila, 4 oz Grand Marnier, 4 oz agave syrup, and 8 oz freshly squeezed lime juice. If you have around 8 thirsty friends add around 8 slices of jalapeños to a pitcher. If you want to know how to make a Spicy Margarita in a pitcher, count your friends and do some simple calculation. Margaritas are epic when served in pitcher-fulls where everyone around the table can help themselves. Make it part of your Barbecue feast this summer.Cheesy nachos or enchiladas with guacamole, sour cream and salsa.Beef short rib, pork belly, and chicken will go down well, but remember to keep it more savory than spicy. Serve a variety of tacos for everyone to share. Tacos: Add some spice to Taco Tuesday.You still want to appreciate the heat of your drink so err on the side of caution when it comes to pairing it with overly spicy food. While it might be tempting to serve some spicy Mexican dishes with this Margarita, we suggest that you don’t go overboard. The best foods to serve with Spicy Margarita You can also add lime zest to the salt for an extra citrus kick. Glass rim: If you want to go the extra mile, go ahead and mix dried chili with your salt to rim the glass.We prefer it without and much more appreciate a subtle heat that doesn’t leave us sweating. But leave the seeds for an even bigger kick. Remove the white membrane and seeds from the pepper before using it in your cocktail. The first, more obvious one, is to use more if you want it spicier and less if you don’t. Jalapeños: We’ve got a few tricks when it comes to using jalapeños.And if orange is your thing, check out some more Grand Marnier cocktails for some zesty inspiration. When combined with agave, you’ll have a lovely and mild sweetness that you expect from a Margarita. Orange liqueur: Choose Grand Marnier for pronounced orange flavor with hints of vanilla and oak.We suggest Espolón Tequila Blanco, because it’s handcrafted with 100% Weber Agave, and you want to infuse your margarita with an agave flavor. When choosing a tequila, remember that silver tequila is best. Tequila: This is the hero of your Margarita.Want to know how to give your Spicy Margarita recipe the right amount of kick and the perfect balance of flavors? We’ve got a few tricks you can use to make the best Spicy Margarita. Oh! And if you’re looking for a fun alternative on our version, check out the Espolón Reposado Spicy Margarita recipe for more fiery inspiration. Make our Spicy Margarita recipe, and then tell us we’re wrong! Challenge accepted. But you don’t have to take our word for it. We have a lot of guts telling you that our version is best. Our Spicy Margarita recipe uses the same classic ingredients as a Lime Margarita, and should be a harmonious balance of sweet, tart, sour and spicy. Adding some spice to your margarita is a lot easier than you might think, and is one of the more popular Margarita types that you can serve. The Margarita has given birth to a massive number of variations and they are dominating cocktail menus across the globe. 1/16/2024 0 Comments Borderlands 3 nimble jackTo become Jack's body double, Timothy's death was faked.During the pre-sequel, Timothy muses that he'd much rather be at home with his mother.He cares for his mother, but she doesn't return the sentiment.He used to have freckles before becoming Jack's body double.By the time of Borderlands 3, he is able to use his previous alias, though the bomb will explode if he leaves the Casino. In the Pre-Sequel, he is legally forbidden to mention his real name after his surgical change, as when asked by Roland, he only says it rhymes with "Jimothy", stating there is a bomb in his face that will detonate if he says his real name.This is mentioned during Intelligences of the Artificial Persuasion. Timothy Lawrence suffers from acrophobia, better known as an abnormal fear of heights.Moxxi admits to having known it was never Jack she met up with, otherwise she wouldn't have shown up, something that makes Timothy happy to learn. He did so disguised as Jack, so he was confused why she agreed to have a dinner date with Jack when "He was the worst". In the ending of the DLC, Timothy, sans one hand, finally asks Moxxi's why she agreed to the date that she had with "Jack" (a detail he has brought up a few times). After averting the casino's destruction, he collapses. Since he is still stuck, Timothy cuts off his cybernetic hand using his laser prison cage and gives it to the Vault Hunters to override the protocol. At first, Timothy tells the Vault Hunter to simply escape, however Moxxi refuses to abandon him and the Vault Hunters agree. After destroying Pretty Boy's robot suit, the casino activates the "Screw Everyone I'm Rich" Protocol, which starts piloting the casino into a black hole. After finding out that Timothy is also trying to get into Jack's Tower, the Vault Hunters team up with him upon Moxxi's approval (who still seems to openly distrust him).īecause Timothy's Winning Hand grants him full access to every facility in the casino, Pretty Boy kidnaps him, and the Vault Hunters must rescue him. His mask is cracked, and his right hand has been grafted with a Hyperion-brand cybernetic authorized access key dubbed "The Winning Hand". After defeating Pretty Boy's Loaders, it is revealed that Timothy Lawrence is trapped in the casino and has been since the death of Handsome Jack. Pretty Boy is sending Loaders after someone in a makeshift hideout. While looting the Handsome Jackpot, the Vault Hunters hear a cry for help. Shoot bullymong-tossed projectiles out of midair."Jack" is called in as part of the Vault Hunter group that assists the real Jack on Helios. (Unlocked upon entering Three Horns - Divide) (Unlocked upon entering Frostburn Canyon) There are 114 general challenges, excluding DLC. They have five levels, awarding 1, 5, 10, 50, and 100 badass ranks respectively. These challenges can be completed in various parts of Pandora. The fire kill challenge "Hot! Too Hot!" is a reference to Spaceballs when Dark Helmet tries to gulp his coffee.Īfter a patch of Borderlands 2, challenges can be reset after 85% of General Challenges have been completed.The shots fired challenge "Who made that man a gunner?" is a reference to Mel Brooks' spoof of Star Wars, SpaceBalls.Robert Oppenheimer, the "father of the atomic bomb", when interviewed about his feelings on the weapon he had designed. The enemy kill challenge "I am become Death." references those same words spoken by J.The phrase itself is a play on "my kung fu is best". The action skill challenge "Your Kung Fu is Best" is a line taken from the television series The X-Files.Challenges do not give money as a reward.Some Challenges are impossible to complete without entering and reentering mission areas many times, and some of them can be very time consuming.A grand total of 758,500 Experience Points can be gained by completing all of the challenges. Challenges differ from Achievements in that they reward Experience Points rather than Gamerscore or Trophies.In the case of "Orbit Achieved" this can potentially result in all of the levels of this Challenge being displayed as each level completes in sequence. The completion of a Challenge will bring up a notice in the top of the screen.Open 5,000 Lootable objects (excluding red chests) Open 1,000 Lootable objects (excluding red chests) Open 250 Lootable objects (excluding red chests) Open 50 Lootable objects (excluding red chests) Kill 2,500 enemies with your Action Skill Kill 1,000 enemies using your Action Skill Kill 25 enemies in succession with no more than 7 seconds in between each kill Kill 15 enemies in succession with no more than 7 seconds in between each kill Kill 10 enemies in succession with no more than 7 seconds in between each kill Kill 5 enemies in succession with no more than 7 seconds in between each kill 1/16/2024 0 Comments Cell stem cellHematopoietic fingerprints: an expression database of stem cells and their progeny. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Identification of Lin −Sca1 +kit +CD34 +Flt3 – short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis. Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing. Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Awakening dormant haematopoietic stem cells. Hematopoietic stem cells count and remember self-renewal divisions. In vivo kinetics of murine hemopoietic stem cells. Dynamic niches in the origination and differentiation of haematopoietic stem cells. High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias. New evidence supporting megakaryocyte-erythrocyte potential of Fflk2/Flt3 + multipotent hematopoietic progenitors. The bone marrow niche for haematopoietic stem cells. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. An acute negative bystander effect of gamma-irradiated recipients on transplanted hematopoietic stem cells. Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells. Hematopoietic stem cell transplantation in its 60s: a platform for cellular therapies. From haematopoietic stem cells to complex differentiation landscapes. Hematopoietic stem cells: concepts, definitions, and the new reality. Therefore, this study uncovers the previously inaccessible kinetics and fate choices of transplanted HSCs in myeloablated recipients at early stage, with implications for clinical applications of HSCs and other stem cells.Įaves, C. Parallel in vitro and in vivo functional experiments supported the paradigm of robust differentiation without substantial HSC expansion during the first week. Based on our transcriptional classifications, most homed HSCs in bone marrow and spleen became multipotent progenitors and, occasionally, some HSCs gave rise to megakaryocytic–erythroid or myeloid precursors. We then applied them in conjunction with functional assays to track the dynamic changes of immunophenotypically purified HSCs in irradiated recipients within the first week after transplantation. Here, using single-cell RNA sequencing, we first obtained the transcriptome-based classifications of 28 haematopoietic cell types. How transplanted haematopoietic stem cells (HSCs) behave soon after they reside in a preconditioned host has not been studied due to technical limitations. |
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